HEMATOLOGICAL AND CYTOGENETIC STUDY OF ADDICTS TAKING ANALGESICS

Abstract

The study was carried out on (72)addicts of analgesics which containthe compound Codeine such as the syrup of cough supressant . The ages of the addicts were between (18-48) years and the period of addiction was 4 to10tewrs . Also,40 persons who do not take any drugs were taken as samples for purpose of compartion.The study aimed at identifying the Hematological measurements which could happen to the addicts of such drugs .As the study aimed at studying the Cytogenetic measurements of the addiicts and mean while identifying the side symptoms which accompany this case of addication. Accordingiy , it has been found out that the over use of the analgesics creates a spiritual desrease P<0.05in the concentration of the Hb%(9.89%)accompanied by an increase of the average of the total serum biliruben (T.S.B) (1.72) mg/dl. Also,there is a spiritual increase of the average of the E.S.R P<0.05 to (26.2) ml/hor.And there is also an increase of the total count average of W.B.C(8986)cell/ml3 associated with a decrease of the immuntiy of the addicts greatly.There occures spiritual differeneces P<0.05 in the rate of the number of the differental W.B.C represented by a decrease in the average of the existence of the Netrophil(37.38)cell/ml3 . on the other hand,there is an increase in the rate of the Monocytes(16.29) cell/ml3 and Lymphocyte(43.17) cell/ml3 . Although there were no chromosomal aberrations or damage (with the exception of one case),there were formation of the Micronuclei (MN) with various forms in most of the individuals of the samples . Also, there was an increase in the Mitotic index factor (MI) with (2.8%)in all the cases which is another indication of creating genetic and chromosomal aberrations which could not be observed easily through the test of the chromosomal Karyotype.