Synthesis and Characterization of New Imine and Dithiocarbamates Ligands with Some Metal Ions

Abstract

New dithiocarbamate and Schiff base derivatives ligands were prepared in this work which are : KL1 = potassium2-( 2,4-dinitrophenyl)hydrazine-1-carbodithioate. KL2 = potassium 5-cyano-3-formyl-1H-indole-1-carbodithioate. L 3 =(Z)-1-(4-((3-chlorobenzylidene)amino)phenyl)ethan-1-one . L 4 =(Z)-4-(((4-acetylphenyl)imino)methyl)benzonitrile. The synthesis of these ligands was based on the NH or NH2 group reaction with CS2 and aldehyde reaction with amine . Dithiocarbamate ligands;KL1 and KL2

were synthesized by mixing 2,4 Dinitrophenylhydrazine and 3, Formyl-1Hindole -5-carbonitrile with carbon disulfide in the presence of KOH as a base in(1:1:1) mol ratio using ethanol as a solvent. The Schiff base ligands; L 3 and L 4 were synthesized by mixing 4-aminoacet phenone with 3-chlorobenzaldehyde and 4-Formylbenzonitrile using ethanol and few drops of glacial acetic acid as catalyst. “V-shaped Schiff base”. Synthesize a new set of transition metals complexes of Au (III),Cu(II),Ni(II) and Co(II) ions. Studies of FT-IR showed a bidentate mode of coordination with metal ions for the carbon disulfide moiety. Additionally, these studies showed asymmetric (aniso bidentate) mode of coordination with sulfur atoms for dithiocarbamate complexes. These ligands and their complexes were isolated and characterized by appropriate physical measurements, flame atomic absorption, FTIR,UV-Vis spectroscopy , the elemental analysis C.H.N.S, NMR spectroscopy, Mass spectroscopy, magnetic susceptibility measurements as well as melting point and Conductivity measurements. II According to the results of the above measurements, the following formulas were suggested for the prepared ligands and their complexes:- Complexes of ligand KL1 (C7H5KN4O4S2) [M(L1 )2(H2O)2]H2O and [Au(L)2(H2O)Cl] which were of octahedral geometry. where M=Ni+2, Cu+2 and Co+2 . Complexes of ligand KL2 (C11H5KN2OS2) [M(L2 )2(H2O)2]H2O and [Au(L)2(H2O)Cl] which were of octahedral geometry. where M=Ni+2, Cu+2 and Co+2 . Complexes of ligand L3 (C15H12ClNO) [M(L3 )2(Cl)2] which were of tetrahedral geometry. where M=Ni+2, Cu+2 and Co+2 . except [Au(L4 )2(Cl)2]Cl which was Square planar geometry. Complexes of ligand L4 (C16H12N2O) [M(L4 )2(Cl)2] which were of tetrahedral geometry. where M=Ni+2, Cu+2 and Co+2. except [Au(L4 )2(Cl)2]Cl which was Square planar geometry. The biological activity of the synthesised ligands and their complexes were studied by using inhibition method for two kinds of bacteria (Staphylococcus aureusa and Escherichia coli) and one type of pathogenic fungus (Candida) .This is to estimates their potential antimicrobial activity. In general the tests show that the ligands and their complexes have good activity against the bacteria types and fungi