the study of biomarkers in uncontrolled type 1 diebatic paients

Abstract

Type I diabetes mellitus (type-I DM) is a complex polygenic autoimmune syndrome resulting in the targeted destroy of ẞ-cell in pancreas that result in deficiency or absence of insulin production. Several studies have been reported the salivary biochemical and biomarkers alterations in diabetic patients. Aims of study: The aims of the study were to evaluate the salivary Interleukin-6 (IL-6), Interleukin-1 Receptor Antagonist (IL-1RA), Secretory Leukocyte Peptidase Inhibitor (SLPI) and matrix metalloproteinase (MMP-2, MMP-8 and MMP-9) in uncontrolled type-I DM, in addition to evaluate of the oral health status (gingival index, pocket depth, attachment loss and DNFT index) with salivary biomarkers and to investigate the association of salivary biomarker to the HbA1c%