Relationships of Omentin-1 and YKL-40 with Some Biochemical Parameters in Men Patients with Type 2 Diabetes Mellitus in AL-Anbar Governorate

Abstract

Insulin shortage leads to a prolonged increase in blood glucose levels or diabetes as ß-cell activity declines or insulin resistance develops (or both). T2DM (Type-2 Diabetes, Mellitus) is the most prevalent sort diabetes in the world. This study aimed to determine Omentin-1 as an anti-inflammatory and YKL-40 as an inflammatory factor and their relationship with some biochemical parameters in male patients with T2DM. To achieve this aim, sixty of T2DM patients with ages range between 31-55 years and 30 apparently healthy control with ages range between 32-55 years were subjected to the study. Where this study included measuring the body mass index BMI, determine glycemic factors, studying the lipid profile, oxidative stress, and inflammatory factors. The results were in the form of Mean ± SD. The findings reveal a significant increase p < 0.05 in BMI kg.m-2 of T2DM patients compared to control subject. The results shown significant increase in glycemic factors in T2DM patients than control subject. In lipid profile there were strong higher in cholesterol CHO , triglyceride TGs, low density lipoprotein LDL-C and very low density lipoprotein VLDL-C levels in T2DM compared to control group. While there VII was decrease in high density lipoprotein HDL-C levels in T2DM compared to control group. The current study shown a significant increase in oxidants and decrease in antioxidants levels in T2DM patients compared to those control group, also increase oxidative stress index OSI levels in T2DM patients. YKL-40 concentration 25.16 ± 8.7 ng/ml was increase p < 0.05 in T2DM compared to those control group 18.17 ±4.7 ng/ml, while there, was. strong reduce p,< 0.05 in Omentin-1 concentration in T2DM 10.57 ± 1.6 ng/ml compared to those control group 12.67 ± 3.9 ng/ml. The study found that the concentrations of Omentin-1 and YKL-40 in serum were associated with BMI, insulin resistance and oxidative stress index. An increase in the level of YKL-40 and decrease Omentin-1level in the serum in patients with T2DM may lead to antioxidant disturbance and increased production of oxidants that cause the development of complications of type 2 diabetes.