The Salivary Secretion and Biochemical Composition Analysis in Patients with Helicobacter pylori Infection

Abstract

Helicobacter pylori (H. pylori) infection defines as an agent who may involve in the occurrence of chronic gastritis, peptic ulcer, gastric cancer and also other known and unknown diseases. This study aims: to determine the salivary flow rate, pH and to compare alteration of salivary enzyme level like Alkaline Phosphatase (ALP), total protein (TP), salivary calcium and urea between subjects with Helicobacter pylori infection and healthy subjects. The saliva and blood samples were collected from patients and healthy control subjects. This study included 52 subjects in total that divided into thirty two subjects with H. pylori infection and twenty subjects were healthy control, this study carried out from (1 March 2017 until 30 July 2017) in the Gastroenterology clinic in Teaching Fallujah Hospital underwent gastrointestinal endoscopy. The salivary sample collection considers as a simple and easy method for analysis. The PH and flow rate in saliva were increased in study group in comparison with healthy controls; there was a highly significant difference between two groups (p<0.001). The salivary ALP level was lowered, whereas salivary urea level was elevated in subjects with Helicobacter pylori, but statistically was non-significant (P>0.05). On other hand the salivary total protein (TP) level in study group was decreased in comparison with control group with statistically significant difference, whereas the salivary calcium level was higher in study group in compared to healthy control with highly significant differences (P<0.001). It was concluded that the Helicobacter pylori infection has obvious influence on salivary composition (like total protein and calcium), salivary flow rate and PH