Correlation between serum anti-müllerian hormone AMH and total testosterone for those with infertile Iraqi men

Abstract

Anti-Müllerian Hormone (AMH) is a dimeric glycoprotein hormone belonging to the transforming growth factorbeta family of the growth of the factor. It is secreted via the sertoli cells and is accountable for the abatement of Müllerian ducts in the male sexual discrimination, but formed if testicular Sertoli cells are existent and can thus aid in the diagnostic road for the unrest the development sexual. Testosterone as an AMH regulator has the possibility of lessening AMH term in Sertoli cells. The objective of the study is to correlate the relationship within serum testosterone-AMH ratio due to adult male infertility, which may provide further clues to investigate the potential regulation and biological mechanism of male fertility. The subjects involved in this study were 26 consecutive male patients aged ranging (22-57) years presented, with infertile complications. Total testosterone, FSH and AMH levels are tested. Variables of the clinical and laboratory display were expressed as mean ± SD. ANOVA was used for the comparison of variables. Pearson correlation coefficients were calculated for the whole study Mean (± SD) age for the patients was 38.08±9.91 (p<0.001), range (22-57) years. The AMH range value (4.3- 9.22) ng/ml and total testosterone was (208-402) ng/mL. Infertile patients are shown a decrease in testosterone levels beyond 40 years of age. It was noted to be reduced with aging progress (388.2 & 288.6 respectively). The AMH level in adult males is significantly elevated, as the class of age increased (5.40.15 & 7.69 respectively). The decline in testosterone and increase in AMH showed a significant inverse correlation (r=-517, p=0.008). The positive correlation between serum testosterone and FSH for males recorded in our study was (r=+0.552, p=0.004). AMH was observed strongly negatively associated with FSH (r =-0.684, p<0.001). In conclusion, Low testosterone levels in infertile men associate with AMH levels. Our result may suggest that the correction of the Testosterone/AMH ratio is important in improving fertility. A prospective controlled study is required to assess the hypothesis generated by the current study.