Prostate Specific Antigen and Prostate Volume; How They are Correlatedin Patients with Benign Prostatic Hyperplasia.

Abstract

Background: Human prostate-specific antigen (PSA) is a glycoprotein with approximately 7% (wVr.rt) carbohydrate. The PSA assay, along q,ith other diagnostic parameters. is considered the most useful early malignancy marker to confirm the diagnosis of prostate disease. Berrign prostatic hyperplasia (BPH) and prostatic cancer are the most cornmon prostate diseases. Otrjecive: The study was designed to assess the diagnostic sensitivity of PSA u'ith different prostate volume (PV) in Iraqi men aged (40 to 88) to define better predictions fbr early detection of prostatic cancer. Method: The subjects involved in this study were I l9 consecutiye male aged (40-88) years with BPl{. Prostate volume (PV) (measured by transrectal ultrasound: TRUS) and PSA densitv (PD) data distribution were evaluated. Variables ofthe clinical and laboratory display were expressed as mean + SD. ANOVA were used for the comparison of variables. Pearson coruelation coefficients were calculated for the whole study. Result: Mean (+ SD) age of the subjects included in this study was 63.23+ I I . l2 years (p<0.01 ).The PSA values in different age groups (40-54, 55--69, 70*), were: 5.71+4.41,7.87+4.55 and 10.22+7.?6 nglmL respectively. There was a significant increase between the second and third group (P < 0.05), while there was a highly signiflcant itrcrease between the first and third age groups (P < 0.01). The coreiation betw'een PV and IPSA was (+0.305) based on the Pearson's correlation co efficient (P<0.01). Conclusion: Increase in prostate volume is associated with increased serum PSA level. A PSA level depicts approxinrate prostate volume and may have clinical potential in the management of BPH patients where PSA and prostate volunre were signi{icantly correlated in BPH patients.