SPECTROSCOPIC EVALUATION OF ACTIVATED CHARCOAL AS A POISON ANTIDOTE FOR GLICLAZIDE DRUG

Abstract

The effects of pH, concentration and time on this process.To evaluate the effect of pH, concentration and time; 50 ml of the drug solution (100 mg/L) were allowed to stand with the activated charcoal for 1 h at pH of 1.5, 4, 7, and 9 for pH study. 50 ml of the drug solution concentrations of 25, 50, 75, and 100 (mg/L) were allowed to stand with 1 g activated charcoal for 1 h for concentration study. 50 mg of the drug solution (100 mg/L) were allowed to stand with the activated charcoal for 15, 30, 45, and 60 min for time study. The concentrations of the adsorbed drug were determined spectrophotometrically.The adsorption of the gliclazide drug on activated charcoal was found to be pH, concentration, and time-dependent.