Effect of Marlubium vulgare Plant on Experimentally Infected Albino Mice with Trichomonas muris Parasite and Compare with Metronidazole Drug

Abstract

This study was conducted to investigate the effect of Marlubium vulgare plant on albino mice experimentally infected with Trichomonas muris parasite and compared it with Metronidazole drug. The oral administration method was used to estimate the effect of the plant extract. where each group of mice was administered a different concentration of the plant alcoholic extract (500, 1500, 2500, 3500) mg/kg, and 30 mg/kg of metronidazole drug was administered to another group, while the control group was administered an equal amount of normal saline solution. The results showed a significant effect of the concentrations of alcoholic extract and the drug metronidazole in the treatment of infected albino mice and showed a high treatment efficiency of 100% with a variation in the time required for complete treatment and complete elimination of parasites. The highest concentration of 3500 mg/kg resulted in complete recovery in the affected albino mice on the fourth day after treatment, while the use of the drug led to a complete recovery on the fifth day after treatment, while the infection in the control group continued to the fifth day and then died. The conclusion of this study confirmed the high therapeutic efficacy of different concentrations of alcoholic extract of M. vulgare plant in treating T. muris parasite in mice experimentally infected with it, which is comparable to the effectiveness of Metronidazole drug.