Estimation of Prolactin Level in Iraqi Diabetic Women of Menopause

Abstract

Menopause is the stage of a woman's life when her menstrual cycles cease for good. In the early stages of menopause, cardiovascular risk significantly rises, primarily as a result of the loss of estrogen's protective effects.Objective: The objective of the current study was to measure the prolactin level in menopausal diabetic Iraqi women as well as the correlation between prolactin levels and other biochemical markers. Methods: This study was carried out on fifty patients women with diabetes type 2 during menopause aged (40–48 years) who visited the National Diabetes Center/AL-Mustansiriya University, Baghdad-Iraq. On the other hand, forty healthy women without diabetes aged (40–48 years) were recruited as control. The study included measurements of the biochemical parameters such as, glycated hemoglobin HbA1c by using (Bio-Rad device, France), Prolactin (PRL) estimated by using (minividas device, Biomerieux-France).Fasting blood sugar (FBS), total cholesterol (TC), triglycerides TG, and high-density lipoprotein HDL were evaluated enzymatically by an auto-analyzer (Kenza 240 TX analyzer) (Biolabo, France).Results: The clinical biochemical markers showed that the serum levels of prolactin, fasting blood sugar (FBS), body mass index (BMI), HBA1c, TC, TG, low-density lipoproteins LDL and very low-density lipoproteins (VLDL) were increased significantly, while the decreased level of serum (HDL) in diabetic women of menopause as compared with healthy women (P=0.0001). Conclusion: As a result of the considerable changes in prolactin levels and altered serum lipid profiles associated with menopause, cardiovascular disease development is at increased risk on its own.