Evaluation of vitamin D3 levels in Iraqi type I diabetes mellitus with and without celiac disease

Abstract

A chronic autoimmune condition affecting the small intestine known as celiac disease is characterized by an increase in intraepithelial lymphocytes. Despite the absence of overt malabsorption, this illness has a high frequency of bone mass derangement because of calcium malabsorption and immunological activation. This study looked at type 1 diabetes mellitus (TIDM) in Iraqis, Diabetes center in Baghdad with and without celiac disease to assess vitamin D3 and other biochemical markers. Eighty Iraqi children, aged between 4 and 16. The total number of study samples is 120 based on the number of participants in these three categories and were divided into (40) children with T1DM and Celiac disease, (20 boys and 20 girls), (40) children with T1DM without Celiac disease, (20 boys and 20 girls), and compared with (40) healthy control children, (20 boys and 20 girls). When compared to controls, there was a highly significant decrease in D3 in T1DM with celiac disease and a highly significant decrease in D3 in T1DM without celiac disease. Children with type 1 diabetes and celiac disease (CD) showed a favorable link between weight and total cholesterol (TC) and a very positive correlation between fasting blood sugar (FBS) and HbA1c in both groups (CD). We can draw the conclusion that low levels of D3 may be crucial to the onset, progression, and management of various autoimmune illnesses, including celiac disease (CD). Despite being a reasonably typical occurrence in children with diabetes, vitamin D deficiency may contribute to the disorder's early onset.