L. Serriola's Protective Impact on Lung Histology Against Benzo(A)Pyrene-Induced Carcinogenesis in Mice

Abstract

Natural plants are considered an important factor in human resistance to diseases. This study aimed to evaluate Protective effect of L. serriole on histological features of Lungs induced by a carcinogen benzo (a) pyrene. The histological study of the lungs of mice showed that there were significant changes in the normal liver structure in the group of

animals that took doses of the carcinogenic substance benzo(a)pyrene, which caused dam- age to the lung tissue. A disease in the normal structure of the lung tissue in a normal way.

The results of the histological diagnosis of the lung showed the presence of hyperemia at the concentration dose of 0.003 mg/kg. When the concentration was given at 0.0015 mg/kg,

it was found that there were histological changes, infiltration of inflammatory cells, com- pared to the control group .The results of changes in the measurements of internal param- eters of the lungs in the group that was taken with a carcinogen benzo(a)pyrene only

showed a significant increase at the level of probability 0.05 in the average measurements

of the internal parameters of the alveoli and bronchi, while the results of the dose of alco- holic extract of wild beer lettuce showed a concentration of 0.006 mg/kg, 0.003 mg/kg, and

0.0015 mg/kg showed a slight increase at a probability level of 0.05 compared to the control group.