Evaluation the effect of clove bud aqueous extract on asthma treatment

Abstract

The aim of this study is to find out how clove buds aqueous extract affected an ovalbumin (OVA)-induced allergic asthma model in mice used as an experimental model. After preparing the clove bud aqueous extract, it is examined as an enzyme inhibitor against 5-lipoxygenase and histidine decarboxylase. Then 30 mice divided into 5 groups to test the effective of clove extract in enhancing the situation of asthma by inhibiting the enzymes. The results showed that the concentration of 50 mg/kg/day gave significant differences versus OVA challenged group and generally using extract gave significant differences. As conclusion of this study we can say that the active constituent of clove extract may act asinhibitor of asthma main enzymes in a synergistic effect comparing of major constituent of extract "eugenol" in case of treating alone.